Of the available traditional eBook formats only the PDF format has the capability to handle such a large number of images easily but PDF readers are not really designed to maximize the enjoyment in reading such a book. Generally you might want to see a whole page yet be able to zoom in to read the text or study details. What is needed is a way to collect the graphic images into a book and then be able to leaf through them like you would a traditional book. Generally the best method of displaying these kinds of books is to scan them in or photograph them and then display the resultant graphic image.
Comic books and other books with a high graphic content can be problematic to read on traditional eBook readers.